Chapter 3: Problem 11
What is the basis for homology among chromosomes?
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Chapter 3: Problem 11
What is the basis for homology among chromosomes?
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Tay-Sachs disease (TSD) is an inborn error of metabolism that results in death, often by the age of \(2 .\) You are a genetic counselor interviewing a phenotypically normal couple who tell you the male had a female first cousin (on his father's side) who died from TSD and the female had a maternal uncle with TSD. There are no other known cases in either of the families, and none of the matings have been between related individuals. Assume that this trait is very rare. (a) Draw a pedigree of the families of this couple, showing the relevant individuals. (b) Calculate the probability that both the male and female are carriers for TSD. (c) What is the probability that neither of them is a carrier? (d) What is the probability that one of them is a carrier and the other is not? [Hint: The \(p\) values in (b), (c), and (d) should equal \(1 .]\)
Albinism, lack of pigmentation in humans, results from an autosomal recessive gene (a). Two parents with normal pigmentation have an albino child. (a) What is the probability that their next child will be albino? (b) What is the probability that their next child will be an albino girl? (c) What is the probability that their next three children will be albino?
Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.) (a) Two normal parents have five children, four normal and one albino. (b) A normal male and an albino female have six children, all normal. (c) A normal male and an albino female have six children, three normal and three albino. (d) Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).
Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor anemia or a major anemia. Assuming that only a single gene pair and two alleles are involved in the inheritance of these conditions, is thalassemia a dominant or recessive disorder?
Galactosemia is a rare recessive disorder caused by the deficiency of galactose- 1 -phosphate uridylyltransferase, leading to the accumulation of toxic levels of galactitol in the blood. It leads to a \(75 \%\) mortality rate in infants as infants cannot metabolize galactose from breast milk. In many countries, newborns are given a heel prick test to measure the levels of metabolic enzymes. As a genetic counselor, how would you explain to a couple whose baby has tested positive for galactosemia where the disease has come from?
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