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Genes important in the embryonic development of animals, such as homeobox-containing genes, have been relatively well conserved during evolution; that is, they are more similar among different species than are many other genes. Explain why this is.

Short Answer

Expert verified

Homeobox genes are responsible for gene regulation or cell differentiation and morphogenesis of the organisms. They act as instructors during the development of all multicellular organisms.

The group of homeobox genes forms head-to-tail organizations in animals. They are preserved and get transformed to every generation from the ancestors.

Step by step solution

01

Definition of homeobox genes

The group of genes or DNA sequences that include around 180 base pairsregulating the anatomical features of the organisms can be called homeobox genes. These are known as developmental controlling genes. They are preserved throughout the evolution process in multicellular organisms.

02

Expression of homeobox genes

Homeobox genes are identified in functional regions of noncoding DNA. Putative regulatory elements regulate the expression of these genes.These are conserved because they are identical to known binding areas for regulatory proteins. The conserved elements participate in the functional divergence of genes and gene regulatory networks.

03

Reason for the conservation of homeobox genes

Understanding the function of the noncoding sequence of DNA and its preservation in the evolutionary process is the primary goal of comparative genetics. However, it is believed that specific protein-coding sequences are conserved to stabilize the organisms' selection process.

The coding part of the DNA is responsible for protein synthesis.The noncoding part of DNA, such as the homeobox gene, regulates gene expression in organisms.Thus, it is not changed during the process of evolution.

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Most popular questions from this chapter

Below are the amino acid sequences (using the single-letter code; see Figure 5.14) of four short segments of the FOXP2 protein from six species: chimpanzee (C), orangutan (O), gorilla (G), rhesus macaque (R), mouse (M), and human (H). These segments contain all of the amino acid differences between the FOXP2 proteins of these species.

Use a highlighter to color any amino acid that varies among the species. (Color that amino acid in all sequences.)

  1. The C, G, R sequences are identical. Identify which lines correspond to those sequences.
  2. The H sequence differs from that of the C, G, R species at two amino acids. Underline the two differences in the H sequence.
  3. The O sequence differs from the C, G, R sequences at one amino acid (having V instead of A) and from the H sequence at three amino acids. Identify the O sequence.
  4. In the M sequence, circle the amino acid(s) that differ from the C, G, R sequences, and draw a square around those that differ from the H sequence.
  5. Primates and rodents diverged between 60 and 100 million years ago, and chimpanzees and humans about 6 million years ago. Compare the amino acid differences between the mouse and the C, G, R species with those between the human and the C, G, R species. What can you conclude?

WHAT IF? There are three times as many Alu elements in the human genome as in the chimpanzee genome. How do you think these extra Alu elements arose in the human genome? Propose a role they might have played in the divergence of these two species.

Homeotic genes

(A) encode transcription factors that control the expression of genes responsible for specific anatomical structures.

(B) are found only in Drosophila and other arthropods.

(C) are the only genes that contain the homeobox domain.

(D) encode proteins that form anatomical structures in the fly.

Insects have three thoracic (trunk) segments. While researchers have found insect fossils with pairs of wings on all three segments, modern insects have wings or related structures on only the second and third segment. It turns out that in modern insects, Hox gene products act to inhibit wing formation on the first segment. The treehopper insect (above) is somewhat of an exception. In addition to having wings on its second segment, the treehopper鈥檚 first segment has an ornate helmet that resembles a set of thorns, which a recent study has found to be a modified, fused pair of 鈥渨ings.鈥 The thorn-like structure helps to camouflage the treehopper in tree branches, thus reducing its risk of predation. Explain how changes in gene regulation could have led to the evolution of such a structure

Describe three examples of errors in cellular processes that lead to DNA duplications.

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