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Who was the first person to isolate the material that came to be known as nucleic acids? a. Frederick Griffith b. Friedrich Miescher c. James Watson d. Oswald Avery

Short Answer

Expert verified
b. Friedrich Miescher

Step by step solution

01

- Understand the Question

The question asks for the name of the person who first isolated nucleic acids, a significant historical scientific achievement.
02

- Identify Key Names

Look at the options given: Frederick Griffith, Friedrich Miescher, James Watson, and Oswald Avery. We need to identify which of these scientists is associated with the discovery and isolation of nucleic acids.
03

- Scientific Contributions

Knowledge of their contributions is essential. Friedrich Miescher is known for first isolating nucleic acids during his study of white blood cells in 1869.
04

- Match Findings to Names

Frederick Griffith is noted for his work on bacterial transformation, James Watson for co-discovering the double-helix structure of DNA, and Oswald Avery for showing that DNA is the material of the gene. Friedrich Miescher is the correct person who first isolated what we now call nucleic acids.

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Key Concepts

These are the key concepts you need to understand to accurately answer the question.

nucleic acids
Nucleic acids are the building blocks of life. They carry genetic information in cells and are essential for the functioning of all living organisms.
Types of Nucleic Acids
There are two main types of nucleic acids: Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA).
DNA carries the genetic blueprint for an organism, while RNA helps in translating this blueprint into proteins.
Structure
Both DNA and RNA are made up of smaller units called nucleotides.
Each nucleotide consists of a sugar molecule, a phosphate group, and a nitrogenous base.
In DNA, these bases are adenine (A), thymine (T), cytosine (C), and guanine (G). In RNA, thymine is replaced with uracil (U).
The arrangement and pairing of these bases form the genetic code, which is unique to every organism.
Function
DNA stores and transmits genetic information from one generation to the next.
RNA converts the genetic information stored in DNA into proteins needed for cellular functions.
Understanding nucleic acids is crucial for fields like genetics, medicine, and biotechnology.
scientific discovery
Scientific discovery is a process that drives our understanding of the natural world.
It involves curiosity, observation, experimentation, and the sharing of findings with the scientific community.
The Role of Experiments
Experiments are crucial for testing hypotheses and theories.
Replication and peer review ensure the credibility and reliability of scientific discoveries.
Historical Breakthroughs
The discovery of nucleic acids by Friedrich Miescher was a turning point in the history of biology.
During his study of white blood cells in 1869, Miescher isolated a substance he called 'nuclein' from the cell nucleus.
This nuclein was later identified as nucleic acids, leading to the understanding of genetic material.
Miescher's discovery laid the foundation for future research in genetics and molecular biology.
Progress in science is often incremental, building upon the findings of previous researchers.
history of biology
The history of biology spans thousands of years and is filled with remarkable discoveries and advancements.
Early Beginnings
Ancient civilizations, like the Greeks and Egyptians, made early observations about plants and animals.
Aristotle, a Greek philosopher, is considered one of the founders of biology for his work on the classification of living things.
Modern Era
The invention of the microscope in the 17th century revolutionized biology, allowing scientists to see cells and microorganisms.
In the 19th century, Charles Darwin's theory of evolution by natural selection provided a unifying principle for understanding the diversity of life.
Genetics and Molecular Biology
Friedrich Miescher's isolation of nucleic acids in 1869 was pivotal for the field of genetics.
Later, the discovery of the double-helix structure of DNA by James Watson and Francis Crick in 1953 furthered our understanding of genetic material.
Today, biology continues to advance with technologies like CRISPR, genomics, and biotechnology.
Understanding the history of biology helps us appreciate the scientific achievements that have shaped our knowledge of life.

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Most popular questions from this chapter

Explain how the components of DNA fit together. a. DNA is composed of nucleotides, consisting of a 5 carbon sugar, a phosphate, and a nitrogenous base. DNA is a double helical structure in which complementary base pairing occurs. Adenine pairs with thymine and guanine pairs with cytosine. Adenine and thymine form two hydrogen bonds and cytosine and guanine form three hydrogen bonds. The two individual strands of DNA are held together by covalent bonds between the phosphate of one nucleotide and sugar of the next. The two strands run anti parallel to each other. b. DNA is composed of nucleotides, consisting of a 5 carbon sugar, a phosphate, and a nitrogenous base. DNA is a double helical structure in which complementary base pairing occurs. Adenine pairs with cytosine and guanine pairs with thymine. Adenine and cytosine form two hydrogen bonds and guanine and thymine form three hydrogen bonds. The two individual strands of DNA are held together by covalent bonds between the phosphate of one nucleotide and sugar of the next. The two strands run anti parallel to each other. c. DNA is composed of nucleotides, consisting of a 5 carbon sugar, a phosphate, and a nitrogenous base. DNA is a double helical structure in which complementary base pairing occurs. Adenine pairs with cytosine and guanine pairs with thymine. Adenine and cytosine form three hydrogen bonds and guanine and thymine form two hydrogen bonds. The two individual strands of DNA are held together by covalent bonds between the phosphate of one nucleotide and sugar of the next. The two strands run antiparallel to each other. d. DNA is composed of nucleotides, consisting of a 5 carbon sugar, a phosphate, and a nitrogenous base. DNA is a double helical structure in which complementary base pairing occurs. Adenine pairs with cytosine and guanine pairs with thymine. Adenine and cytosine form three hydrogen bonds and guanine and thymine form two hydrogen bonds. The two individual strands of DNA are held together by covalent bonds between the phosphate of one nucleotide and sugar of the next. The two strands run parallel to each other.

Which of the following would be a good application of plasmid transformation? a. to make copies of DNA b. to isolate a change in a single nucleotide c. to separate DNA fragments d. to sequence DNA

A mutation has occurred in the DNA and in the mRNA for a gene. Discuss which would have a more significant effect on gene expression. Why? a. Both will result in the production of defective proteins. The DNA mutation, if not corrected, is permanent, while the mRNA mutation will only affect proteins made from that mRNA strand. Production of defective protein ceases when the mRNA strand deteriorates. b. Both will result in the production of defective proteins. The DNA mutation, if not corrected, is permanent, while the mRNA mutation will not affect proteins made from that mRNA strand. Production of defective protein continues when the mRNA strand deteriorates. c. Only DNA will result in the production of defective proteins. The DNA mutation, if not corrected, is permanent. Production of defective protein ceases when the DNA strand deteriorates. d. Only mRNA will result in the production of defective proteins. The mRNA mutation will only affect proteins made from that mRNA strand. Production of defective protein ceases when the mRNA strand deteriorates.

Explain the events taking place at the replication fork. If the gene for helicase is mutated, what part of replication will be affected? a. Helicase separates the DNA strands at the origin of replication. Topoisomerase breaks and reforms DNA鈥檚 phosphate backbone ahead of the replication fork, thereby relieving the pressure. Single-stranded binding proteins prevent reforming of DNA. Primase synthesizes RNA primer which is used by DNA polymerase to form a daughter strand. If helicase is mutated, the DNA strands will not be separated at the beginning of replication. b. Helicase joins the DNA strands together at the origin of replication. Topoisomerase breaks and reforms DNA鈥檚 phosphate backbone after the replication fork, thereby relieving the pressure. Single-stranded binding proteins prevent reforming of DNA. Primase synthesizes RNA primer which is used by DNA polymerase to form a daughter strand. If helicase is mutated, the DNA strands will not be joined together at the beginning of replication. c. Helicase separates the DNA strands at the origin of replication. Topoisomerase breaks and reforms DNA鈥檚 sugar backbone ahead of the replication fork, thereby increasing the pressure. Single-stranded binding proteins prevent reforming of DNA. Primase synthesizes DNA primer which is used by DNA polymerase to form a daughter strand. If helicase is mutated, the DNA strands will be separated at the beginning of replication. d. Helicase separates the DNA strands at the origin of replication. Topoisomerase breaks and reforms DNA鈥檚 sugar backbone ahead of the replication fork, thereby relieving the pressure. Single-stranded binding proteins prevent reforming of DNA. Primase synthesizes DNA primer which is used by RNA polymerase to form a parent strand. If helicase is mutated, the DNA strands will be separated at the beginning of replication.

Prior to the work of Hershey and Chase, scientists thought that inheritance involved 鈥渘ucleoproteins.鈥 The amount of information to be transmitted between generations did not seem consistent with the chemical simplicity of the few nucleotides found in polymers of deoxyribonucleic acids in comparison to the diversity of protein polymers. Briefly explain: 鈥 the relationship between the structure of polymeric DNA and the information stored 鈥 the relationship between the interactions between base pairs on complementary strands of the double helix and Chargaff鈥檚 observation on the relative abundance of nucleotides in DNA 鈥 the meaning of the statement from the Nature publication on the structure of DNA by Watson and Crick: 鈥淚t has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.鈥

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