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Chapter 10: Q. 40 (page 278)

Outline the steps that lead to a cell becoming cancerous

Short Answer

Expert verified

Mutations in genes can lead to a cell becoming dangerous.

Step by step solution

01

Step 1. What is p53?

p53 is a gene that codes for a protein that controls the cell cycle and hence functions as a tumor eliminator. It is also known as TP53 or tumor protein.

02

Step 2. In normal condition

p53 is used to track DNA and the supply of oxygen. And if the damage is noticed then p53 will activate the repair mechanism to take place by arresting the cell cycle. the apoptosis takes place only if the damage can not be repaired.

03

Step 3. In case of Mutated p53

When a cell with abnormal p53 protein is there then it can not restore the harmed DNA.

It also cannot signal apoptosis.

Due to this the cell cycle pursues and the damaged cell continues to divide.

This finally leads to the cell becoming cancerous.

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Most popular questions from this chapter

Which negative regulatory molecule can trigger cell suicide (apoptosis) if vital cell cycle events do not occur?

a. p53

b. p21

c. retinoblastoma protein (Rb)

d. cyclin-dependent kinase (Cdk)

Eukaryotic chromosomes are thousands of times longer than a typical cell. Explain how chromosomes can fit inside a eukaryotic nucleus.

What is the relationship between a genome,

chromosomes, and genes?

FtsZ proteins direct the formation of a _______ that will eventually form the new cell walls of the daughter cells.

a. contractile ring

b. cell plate

c. cytoskeleton

d. septum

Figure 10.6 Which of the following is the correct order of events in mitosis?

a. Sister chromatids line up at the metaphase plate. The kinetochore becomes attached to the mitotic spindle. The nucleus reforms and the cell divides. Cohesin proteins break down and the sister chromatids separate.

b. The kinetochore becomes attached to the mitotic spindle. Cohesin proteins break down and the sister chromatids separate. Sister chromatids line up at the metaphase plate. The nucleus reforms and

the cell divides.

c. The kinetochore becomes attached to the cohesin

proteins. Sister chromatids line up at the metaphase plate. The kinetochore breaks down and the sister chromatids separate. The nucleus reforms and the cell divides.

d. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. Cohesin proteins break down and the sister chromatids separate. The nucleus reforms and the

cell divides.
See all solutions

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