Chapter 5: Problem 5
Explain why active transport of an ion shows saturation kinetics, whereas transport of an ion through an ion channel does not.
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Chapter 5: Problem 5
Explain why active transport of an ion shows saturation kinetics, whereas transport of an ion through an ion channel does not.
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People often say things like "A city has reached equilibrium size" or "A person has reached equilibrium between needs and wants." Discuss whether these uses of equilibrium are compatible with the word's thermodynamic meaning.
(a) Life-threatening diarrhea is a shockingly common problem in the developing world. People with life-threatening diarrhea are often \(\mathrm{Na}^{+}\)-depleted, and to save their lives, replacing \(\mathrm{Na}^{+}\)is essential. However, "raw" \(\mathrm{Na}^{+}\)in the intestines is not absorbed. Drinking a solution of \(\mathrm{NaCl}\) does not, therefore, replenish body \(\mathrm{Na}^{+}\). In fact, drinking such a solution can actually worsen a person's situation by osmotically dehydrating the blood and other body fluids. Explain how drinking an \(\mathrm{NaCl}\) solution could have this effect. (b) One of the greatest physiological discoveries of the twentieth century was that drinking a solution of mixed glucose and \(\mathrm{NaCl}\) can promote restoration of the body's \(\mathrm{Na}^{+}\). With the glucose concentration high enough in the solution, glucose "drives" the glucose- \(\mathrm{Na}^{+}\)cotransporter in the apical membranes of intestinal epithelial cells, promoting \(\mathrm{Na}^{+}\)uptake in sick people. Explain the concept behind this manipulation of the cotransporter for therapeutic ends. The approach has saved millions of lives.
Consider three groups of solutes: (i) steroid hormones, fatty acids, and other lipids; (ii) inorganic ions; and (iii) polar organic solutes such as glucose and amino acids. What is the principal mechanism by which each group crosses cell membranes passively? Why do members of the first group cross in a fundamentally different way from solutes belonging to the other two groups?
Amphibian eggs laid in freshwater exhibit low water permeabilities and thus do not swell and burst osmotically. When investigators first believed they had identified an aquaporin, they manipulated amphibian eggs so the eggs expressed the purported aquaporin protein. When the investigators observed those eggs swell and burst, they knew they had made a monumental discovery: They had found the first aquaporin. Recalling what we have discussed in the text of this chapter regarding red blood cells, explain why this experiment provided convincing evidence for channel-mediated water transport.
When we discussed the microscopic mechanism of simple diffusion, we made the following point: After the concentrations of glucose on the two sides of a membrane have become equal, glucose molecules continue to move at random from left to right and from right to left; the numbers of glucose molecules going in the two directions are equal, however, explaining why the two concentrations stay equal once they have become equal. Taking advantage of the options provided by multiple isotopes of elements, how could you do an experiment, in an actual physical system, to determine whether the point we have made here is true?
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